Firefigthers from Stockhill, Arnold and Hucknall attended the scene of a fire in the kitchen of a property on Cinderhill Road.
The fire was caused by an exploding camping cylinder.
One man and a woman managed to to escape. Another woman was rescued by firefighters. Two people were taken to hospital with minor injuries.
Crews wearing breathing apparatus used a hose reel and a gas detector to extinguish the fire.
The incident had been dealt with by 6.04am.